In recent decades, one of the most important concerns of organizational managers has been to keep business strategy and information technology alignment in a volatile environment. Hence, companies need flexible IT capable to react business changes rapidly and to align with business strategies. To this end, present study is conducted to examine the role of IT flexibility in strategic alignment. Research population consists of active scholars and practitioners in Qom province’s computer researches institutes that are specialized in two strategies and IT fields. They were selected by accessible technique. A questionnaire was use to collection research data. This is an applied study conducted by descriptive – correlation method. Results from SEM indicate that IT flexibility variables (connectivity, adaptability and modularity) have positive and direct impact on strategic alignment while the impact by modularity on strategic alignment is higher than other variables.