Information technology can improve the performance of organizations by optimizing the capabilities of the organization's components. Management of knowledge and human resources as a key lever by reducing costs shows its effect on playing a role in a competitive business environment. This research analyzed the importance and capabilities of information technology, knowledge management and human resources on the organizational performance of Khorasan Regional Electricity Company. The present study was conducted through a survey method in order to collect information and using analytical tools and qualitative literature, the relationships between information technology, knowledge management and organizational performance. Confirmatory factor analysis was used to evaluate the proposed measurement models, and structural equation modeling was used to evaluate the structural models as well as to test the hypotheses. The results of the evaluations showed that information technology and human resource management, in turn, improve knowledge management, and finally, empowering the system through knowledge management and human resource management by information technology method leads to qualitative-quantitative improvement of organizational performance. In general, by evaluating and studying the interactions of knowledge and human resources in small and large units that have been active in employment and business for a long time, it is possible to provide an overview of the effectiveness of information technology to reduce costs, manage and better use resources, and provide suitable criteria.